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Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial

Received: 30 April 2015     Accepted: 9 May 2015     Published: 21 May 2015
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Abstract

Background: Fibrin-based biological adhesives are used for tissue adhesion improving the outcome of gastrointestinal sutures. The objective was to assess the effectiveness of fibrin-based biological adhesives for prevention of anastomotic leakage in high-risk gastrointestinal anastomoses. Methods: A randomized clinical trial was designed to recruit patients underwent a rectal resection surgery. A subgroup of patients with rectal anastomosis were recruited from 2 different hospital centres. Patients in which a biological fibrin-based biological adhesive was applied to the suture line (study group) were compared versus a control group under standard practice. The main outcome measures was presence or absence of leakage and need for reoperation. Results: Thirty seven patients underwent a rectal resection and anastomosis. In 21 standard practice was applied and a fibrin-based adhesive was used in 16. Fourteen patients (37.8%) had a clinical or subclinical anastomotic leak, 11 belonging to control group versus 3 patients in the study group (p-value of 0.04). Statistically significant difference (p-value of 0.048) in the need for reoperation. We found no association between the use of drains and anastomotic leakage. There were only 3 leaks in the group in which a drain was placed, as compared to 11 leaks in the group in which no drain was placed, but these findings were probably due to chance (p = 0.54). Conclusions: The use of these adhesives could not only reduce serious postoperative complications related to dehiscence but also improve the prognosis and oncological outcome of rectal and sigmoid cancer treatment.

Published in Journal of Surgery (Volume 3, Issue 3)
DOI 10.11648/j.js.20150303.13
Page(s) 26-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Fibrin Tissue Adhesive, Anastomotic Leak, Digestive System Surgical Procedures, Randomized Controlled Trial, Spain

References
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Cite This Article
  • APA Style

    Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Esteves, Irene Arjona Medina, Mercedes Sanz Sánchez, et al. (2015). Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial. Journal of Surgery, 3(3), 26-31. https://doi.org/10.11648/j.js.20150303.13

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    ACS Style

    Jesús Lago Oliver; Salvador Argudo Garijo; Mauricio Burneo Esteves; Irene Arjona Medina; Mercedes Sanz Sánchez, et al. Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial. J. Surg. 2015, 3(3), 26-31. doi: 10.11648/j.js.20150303.13

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    AMA Style

    Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Esteves, Irene Arjona Medina, Mercedes Sanz Sánchez, et al. Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial. J Surg. 2015;3(3):26-31. doi: 10.11648/j.js.20150303.13

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  • @article{10.11648/j.js.20150303.13,
      author = {Jesús Lago Oliver and Salvador Argudo Garijo and Mauricio Burneo Esteves and Irene Arjona Medina and Mercedes Sanz Sánchez and Jorge Martín Gil and Fernando Turégano Fuentes and Antonio Torres García},
      title = {Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial},
      journal = {Journal of Surgery},
      volume = {3},
      number = {3},
      pages = {26-31},
      doi = {10.11648/j.js.20150303.13},
      url = {https://doi.org/10.11648/j.js.20150303.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150303.13},
      abstract = {Background: Fibrin-based biological adhesives are used for tissue adhesion improving the outcome of gastrointestinal sutures. The objective was to assess the effectiveness of fibrin-based biological adhesives for prevention of anastomotic leakage in high-risk gastrointestinal anastomoses. Methods: A randomized clinical trial was designed to recruit patients underwent a rectal resection surgery. A subgroup of patients with rectal anastomosis were recruited from 2 different hospital centres. Patients in which a biological fibrin-based biological adhesive was applied to the suture line (study group) were compared versus a control group under standard practice. The main outcome measures was presence or absence of leakage and need for reoperation. Results: Thirty seven patients underwent a rectal resection and anastomosis. In 21 standard practice was applied and a fibrin-based adhesive was used in 16. Fourteen patients (37.8%) had a clinical or subclinical anastomotic leak, 11 belonging to control group versus 3 patients in the study group (p-value of 0.04). Statistically significant difference (p-value of 0.048) in the need for reoperation. We found no association between the use of drains and anastomotic leakage. There were only 3 leaks in the group in which a drain was placed, as compared to 11 leaks in the group in which no drain was placed, but these findings were probably due to chance (p = 0.54). Conclusions: The use of these adhesives could not only reduce serious postoperative complications related to dehiscence but also improve the prognosis and oncological outcome of rectal and sigmoid cancer treatment.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial
    AU  - Jesús Lago Oliver
    AU  - Salvador Argudo Garijo
    AU  - Mauricio Burneo Esteves
    AU  - Irene Arjona Medina
    AU  - Mercedes Sanz Sánchez
    AU  - Jorge Martín Gil
    AU  - Fernando Turégano Fuentes
    AU  - Antonio Torres García
    Y1  - 2015/05/21
    PY  - 2015
    N1  - https://doi.org/10.11648/j.js.20150303.13
    DO  - 10.11648/j.js.20150303.13
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 26
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20150303.13
    AB  - Background: Fibrin-based biological adhesives are used for tissue adhesion improving the outcome of gastrointestinal sutures. The objective was to assess the effectiveness of fibrin-based biological adhesives for prevention of anastomotic leakage in high-risk gastrointestinal anastomoses. Methods: A randomized clinical trial was designed to recruit patients underwent a rectal resection surgery. A subgroup of patients with rectal anastomosis were recruited from 2 different hospital centres. Patients in which a biological fibrin-based biological adhesive was applied to the suture line (study group) were compared versus a control group under standard practice. The main outcome measures was presence or absence of leakage and need for reoperation. Results: Thirty seven patients underwent a rectal resection and anastomosis. In 21 standard practice was applied and a fibrin-based adhesive was used in 16. Fourteen patients (37.8%) had a clinical or subclinical anastomotic leak, 11 belonging to control group versus 3 patients in the study group (p-value of 0.04). Statistically significant difference (p-value of 0.048) in the need for reoperation. We found no association between the use of drains and anastomotic leakage. There were only 3 leaks in the group in which a drain was placed, as compared to 11 leaks in the group in which no drain was placed, but these findings were probably due to chance (p = 0.54). Conclusions: The use of these adhesives could not only reduce serious postoperative complications related to dehiscence but also improve the prognosis and oncological outcome of rectal and sigmoid cancer treatment.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Department of Surgery, University General Hospital Gregorio Mara?ón, Madrid, Spain

  • Department of Surgery, Southeast Hospital, Madrid, Spain

  • Department of Surgery, University General Hospital Gregorio Mara?ón, Madrid, Spain

  • Department of Surgery, General Hospital of Ciudad Real, Ciudad Real, Spain

  • Department of Surgery, University General Hospital Gregorio Mara?ón, Madrid, Spain

  • Department of Surgery, University General Hospital Gregorio Mara?ón, Madrid, Spain

  • Department of General Surgery II, University General Hospital Gregorio Mara?ón, Madrid, Spain

  • Department of Surgery, San Carlos University Hospital, Madrid, Spain

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